How Does Sildenafil Citrate Work?
Sildenafil citrate is a medication that belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It was initially developed for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain). However, during clinical trials, it was discovered to have a significant effect on penile erection. This led to its approval by the U.S. Food and Drug Administration (FDA) for the treatment of erectile dysfunction in 1998. How Does Sildenafil Citrate Work? Sildenafil citrate works by inhibiting the enzyme PDE5, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP). cGMP is a chemical messenger that plays a crucial role in the relaxation of smooth muscles and the dilation of blood vessels in the penis. By inhibiting PDE5, sildenafil citrate allows cGMP to accumulate, promoting increased blood flow to the penile tissues and facilitating an erection. The Use of Sildenafil Citrate for Erectile Dysfunction Sildenafil ci...